Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways.
説明 | Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways. |
In vitro | METHODS AND RESULTS: Two triterpenes, alisol M 23-acetate and Alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators. Indeed, in the transient transfection reporter assays, alisol M 23-acetate and Alisol A 23-acetate transactivated AR in dose-dependent manner, while they transrepressed the transactivation effects exerted by agonist-activated PR and GR. Through molecular modeling docking studies, they were shown to respectively interact with AR, PR, or GR ligand binding pocket fairly well. CONCLUSIONS: All these results indicate that alisol M 23-acetate and Alisol A 23-acetate from Alisma orientalis might possess therapeutic effects through their modulation of AR, PR, and GR pathways. |
植物由来 |
分子量 | 532.762 |
分子式 | C32H52O6 |
CAS No. | 19865-75-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Alisol A 23-acetate 19865-75-9 Alisol A Alisol A 23acetate Alisol A 23 acetate Inhibitor inhibitor inhibit