Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amphethinile is an anti-tubulin agent. The Ka of Amphethinile with tubulin is 1.3 μM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
ターゲット&IC50 | Tubulin: 1.3 μM (Ka) |
In vitro | Amphethinile exhibits strong binding affinity to microtubule proteins (Ka=1.3 µM) and effectively inhibits the assembly of tubulin without promoting its rapid disassembly. Its inhibitory concentration for assembly (12 μM) closely matches that of colchicine (11 μM), and it competes for the same binding sites as colchicine, though not for those targeted by vinca alkaloids. Furthermore, amphethinile enhances the GTPase activity of tubulin, akin to the effects observed with combretastatin A4 and 2-methoxy-5-(2',3',4'-trimethoxyphenyl) tropolone (MTPT). It causes a G2/M phase block in the cell cycle and demonstrates equal toxicity towards both parental and daunorubicin-resistant P388 cells. Unlike daunorubicin, vincristine, and vinblastine, where resistance in P388 cells is linked to reduced drug accumulation, amphethinile's effectiveness is less affected by such resistance mechanisms. |
別名 | Amphetinile, CRC 82-07 |
分子量 | 265.33 |
分子式 | C15H11N3S |
CAS No. | 91531-98-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Amphethinile 91531-98-5 Others Amphetinile CRC 82-07 Inhibitor inhibitor inhibit