Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally administred multi-targeted tyrosine kinase inhibitor that exhibits strong efficacy against mutant forms of c-Kit, PDGFRα, Flt3, c-Met, and c-Ret, while also acting as a suppressor of DNA repair by inhibiting the RAD51 protein, which is crucial for repairing DNA damage[1][2][3]. This dual mechanism contributes to its antineoplastic activity[4].
説明 | Amuvatinib hydrochloride (MP470 hydrochloride) is an orally administred multi-targeted tyrosine kinase inhibitor that exhibits strong efficacy against mutant forms of c-Kit, PDGFRα, Flt3, c-Met, and c-Ret, while also acting as a suppressor of DNA repair by inhibiting the RAD51 protein, which is crucial for repairing DNA damage[1][2][3]. This dual mechanism contributes to its antineoplastic activity[4]. |
ターゲット&IC50 | PDGFRα (D842V):81 nM, c-Kit (D816H):10 nM, c-Kit (V560G):34 nM, c-Kit (D816V):950 nM, PDGFRα (V561D):40 nM, c-Kit (V654A):127 nM |
別名 | HPK 56 hydrochloride, MP470 hydrochloride |
分子量 | 483.97 |
分子式 | C23H22ClN5O3S |
CAS No. | 1055986-67-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Amuvatinib hydrochloride 1055986-67-8 Others HPK 56 hydrochloride MP470 hydrochloride MP-470 Hydrochloride HPK56 Hydrochloride MP 470 Hydrochloride HPK 56 Hydrochloride Amuvatinib Hydrochloride MP470 Hydrochloride HPK-56 Hydrochloride Inhibitor inhibitor inhibit