Powder: -20°C for 3 years | In solvent: -80°C for 1 year
B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 38,500 | |||
10 mg | 在庫あり | ¥ 57,000 | |||
25 mg | 在庫あり | ¥ 96,000 | |||
50 mg | 在庫あり | ¥ 140,500 | |||
100 mg | 在庫あり | ¥ 180,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins. |
ターゲット&IC50 | NF-κB-inducing kinase (NIK):4.2 nM (Ki) |
In vitro | B022 treatment of Hepa1 cells (0 μM, 0.5 μM, 5 μM; 12 hours) can suppress NIK-induced p52 formation in a dose-dependent manner[1]. |
In vivo | In STOP-NIK male mice (8 weeks old) infected with Ad-cre, B022 (30 mg/kg; intravenous injection; twice daily; for 10 days) completely prevents the lethal effects induced by abnormally high levels of hepatic NIK in mice. It inhibits the majority of the deteriorating effects caused by aberrant activation of hepatic NIK[1]. |
分子量 | 397.88 |
分子式 | C19H16ClN5OS |
CAS No. | 1202764-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (502.66 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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B022 1202764-53-1 NF-Κb NF-κB B-022 B 022 Inhibitor inhibitor inhibit