store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 14,000 | |||
2 mg | 在庫あり | ¥ 20,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | お問い合わせ | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 47,500 |
説明 | BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM. |
ターゲット&IC50 | BTK:3 nM |
In vitro | In human Ramos B cells, BMS-935177 inhibits calcium flux with an IC50 of 27 nM. BMS-935177 inhibits CD69 surface expression in peripheral B cells stimulated with antiIgM and anti-IgG. Against IgG-containing immune complexdriven low affinity activating FcγRIIa and FcγRIII end points in peripheral blood mononuclear cells, BMS-935177 effectively inhibits TNFα production (IC50 = 14 nM). BMS-935177 shows mean IC50 values of 550 and 2060 nM in human and mouse whole blood, respectively[1]. |
In vivo | BMS-935177(5, 20, and 45 mg/kg) inhibits anti-KLH antibodies of the IgG isotype at day 14, with statistically significant reductions at all doses. In satellite mice, BMS-935177 (5 mg/kg) maintains the plasma concentration above the mouse whole blood BCR-stimulated CD69 IC50 value of 2 μM for only 5 h. BMS-935177(10, 20, and 30 mg/kg) provides dose-dependently reduces both the severity and incidence of clinically evident disease in this rodent model of RA. BMS-935177(10 mg/kg) reduces the disease severity about 40%, and the percentage of animals showing any signs of disease is reduced by a third[1]. |
分子量 | 502.56 |
分子式 | C31H26N4O3 |
CAS No. | 1231889-53-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 117mg/mL (232.8mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-935177 1231889-53-4 Angiogenesis Tyrosine Kinase/Adaptors BTK BMS935177 BMS 935177 Inhibitor inhibitor inhibit