Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPN-15606, an orally active γ-secretase modulator (GSM), significantly reduces Aβ42 and Aβ40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits favorable pharmacokinetic/pharmacodynamic (PK/PD) properties, such as bioavailability, half-life, and clearance. Importantly, BPN-15606 markedly decreases Aβ42 and Aβ40 levels in the central nervous system of both rats and mice[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約6-8 週間 | ¥ 57,000 |
25 mg | 約6-8 週間 | ¥ 176,000 |
50 mg | 約6-8 週間 | ¥ 228,500 |
100 mg | 約6-8 週間 | ¥ 342,000 |
1 mL * 10 mM (in DMSO) | 約6-8 週間 | ¥ 65,500 |
説明 | BPN-15606, an orally active γ-secretase modulator (GSM), significantly reduces Aβ42 and Aβ40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits favorable pharmacokinetic/pharmacodynamic (PK/PD) properties, such as bioavailability, half-life, and clearance. Importantly, BPN-15606 markedly decreases Aβ42 and Aβ40 levels in the central nervous system of both rats and mice[1]. |
In vivo | Administered orally at a dosage of 25 mg/kg, BPN-15606 significantly impacts Aβ42 and Aβ40 levels in both the brain and plasma of C57BL/6 mice, showing effects approximately 30–60 minutes after administration and lasting for over 24 hours [1]. When given at dosages of 5 mg/kg, 25 mg/kg, and 50 mg/kg over 9 days, it demonstrates a dose-dependent reduction of Aβ42 and Aβ40 levels in rat CSF [1]. Moreover, administered at 10 mg/kg, 25 mg/kg, and 50 mg/kg for 7 days, BPN-15606 shows remarkable dose-dependent efficacy in lowering Aβ42 and Aβ40 levels in both the plasma and brain of mice [1]. |
分子量 | 418.47 |
分子式 | C23H23FN6O |
CAS No. | 1914989-49-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BPN-15606 1914989-49-3 Others BPN 15606 BPN15606 Inhibitor inhibitor inhibit