Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schizophrenia.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schizophrenia. |
ターゲット&IC50 | D2 receptor:8.83 (pKi), 5-HT1A receptor:6.37(pEC50), 5-HT1A receptor:7.19 (pKi) |
In vitro | Bifeprunox has a pKi of 8 at h5-HT1A receptors (Emax: 70%) [1]. |
In vivo | Bifeprunox (0.001-2.5 mg/kg) reduces marble burying in mice [2]. Bifeprunox (4-250 μg/kg) influences nicotine-seeking behavior in response to drug-associated stimuli in rats [3]. |
分子量 | 385.46 |
分子式 | C24H23N3O2 |
CAS No. | 350992-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Bifeprunox 350992-10-8 Others Inhibitor inhibitor inhibit