Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP-53153 is a steroidal inhibitor of 5 alpha-reductase (IC50s: 36 and 262 nM in rat and human prostatic tissue).
ターゲット&IC50 | 5α reductase (human):262 nM , 5α reductase (rat):36 nM |
In vivo | CGP-53153, administered orally at a dose of 0.01 mg/kg, significantly reduces T-propionate-induced prostate growth. Further, it notably lowers prostate weight by 31% and 37% at doses of 3 and 10 mg/kg, respectively. A 12-week treatment regimen with CGP-53153 diminishes prostate volume by over 70% in individual dogs without affecting body weight or the weight of any tested organ. |
分子量 | 383.53 |
分子式 | C23H33N3O2 |
CAS No. | 149281-19-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CGP-53153 149281-19-6 Others CGP 53153 CGP53153 Inhibitor inhibitor inhibit