Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation that lead to novel therapeutic approaches for the treatment of skin hyperproliferative disorders.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 349,000 |
50 mg | 約10-14 週間 | ¥ 454,500 |
100 mg | 約10-14 週間 | ¥ 574,000 |
説明 | Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation that lead to novel therapeutic approaches for the treatment of skin hyperproliferative disorders. |
In vitro | Treatment with Casein Kinase II Inhibitor IV enhances early differentiation in human epidermal keratinocytes (NHEKs), evidenced by increased keratins 1 and 10 expression at 48 hours. Levels of IVL and TGM also rise at 72 hours and remain elevated at 96 hours. Furthermore, this treatment induces expression of loricrin, a marker of terminal differentiation, at later stages. mRNA expression analysis corroborates these findings, showing early upregulation of keratinocyte differentiation marker genes keratin 1 (5.4-fold) and keratin 10 (5.4-fold) at 12 and 24 hours, while genes marking terminal differentiation, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are significantly increased at 36 and 48 hours. These consistent results underscore Casein Kinase II Inhibitor IV's capacity to drive the differentiation of epidermal progenitor cells into terminally differentiated keratinocytes [1]. |
別名 | Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base) |
分子量 | 465.93 |
分子式 | C24H24ClN5O3 |
CAS No. | 2320347-54-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Casein Kinase II Inhibitor IV Hydrochloride 2320347-54-2 Others Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base) 863598-09-8 free base 863598-09-8 Inhibitor inhibitor inhibit