Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 49,500 |
25 mg | 約8-10 週間 | ¥ 314,500 |
50 mg | 約8-10 週間 | ¥ 411,000 |
100 mg | 約8-10 週間 | ¥ 622,000 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 111,500 |
説明 | Celgosivir hydrochloride (MBI 3253 hydrochloride) is an α-glucosidase I inhibitor and inhibits bovine viral diarrhoea virus (BVDV) (IC50: 1.27 μM). |
ターゲット&IC50 | α-glucosidase I:1.27 μM |
In vitro | Celgosivir is more effective (IC50: 20 μM) than the parent molecule (IC50: 254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0 μM) [1]. BVDV is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively [2]. Celgosivir inhibits DENV2 replication with an EC50 of 0.2 μM. The EC50 values against DENV1, 3, and 4 are less than 0.7 μM [3]. |
In vivo | During primary infection with a mouse-adapted DENV strain S221, mice show increased viremia on day 3, yet 80% survived day 10 with a virus completely cleared by day 8 [3]. Celgosivir (50 mg/kg, BID for 5 days) fully protects AG129 mice from lethal infection with a mouse-adapted dengue virus and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25, or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice show that it rapidly metabolizes to castanospermine [4]. |
別名 | MX3253 hydrochloride, MBI 3253 hydrochloride, MDL 28574 hydrochloride |
分子量 | 295.76 |
分子式 | C12H22ClNO5 |
CAS No. | 141117-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (338.11 mM)
DMSO: 100 mg/mL (338.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Celgosivir hydrochloride 141117-12-6 Others MX3253 hydrochloride MBI-3253 Hydrochloride MX-3253 Hydrochloride MX3253 Hydrochloride MDL 28574 Hydrochloride MDL-28574 Hydrochloride MX 3253 Hydrochloride MBI 3253 Hydrochloride MBI 3253 hydrochloride MDL 28574 hydrochloride Celgosivir Hydrochloride MBI3253 Hydrochloride MDL28574 Hydrochloride Inhibitor inhibitor inhibit