Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.
ターゲット&IC50 | MNK:50 nM, PKC1:50 nM, PKC1:7 nM (ki) |
In vivo | Treatment with either Cercosporamide or Ara-C alone markedly inhibits xenograft growth compared to their respective controls, achieving statistical significance (P<0.011 for 10 mg/kg Cercosporamide twice-daily; P<0.006 for 20 mg/kg Cercosporamide daily; P<0.0374 for Ara-C). The combined application of Cercosporamide (10 mg/kg twice daily) with Ara-C substantially enhances efficacy beyond that of either compound used singly. Similarly, the synergy of Cercosporamide (20 mg/kg daily) with Ara-C markedly reduces tumor growth compared to both captisol (P<0.0001) and water controls (P=0.0003), albeit without significant superiority over the individual effects of either Cercosporamide (20 mg/kg) or Ara-C alone. |
別名 | (-)-Cercosporamide |
分子量 | 331.28 |
分子式 | C16H13NO7 |
CAS No. | 131436-22-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Cercosporamide 131436-22-1 Others (-)-Cercosporamide Inhibitor inhibitor inhibit