store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
ターゲット&IC50 | F-actin (Mg2+/K+):1.4 nM (Kd), F-actin (Mg2+):2.2 nM (Kd) |
In vivo | Cytochalasin B, administered intraperitoneally at doses of 10, 25, and 50 mg/kg, enhances the lifespan of Balb/c mice afflicted with P388/ADR leukemias in a dose-dependent manner. Specifically, a 50 mg/kg dose of Cytochalasin B results in a 10% increase in long-term survival rates for mice with multidrug-resistant P388/ADR leukemia, and a 40% increase in long-term survival for those with the drug-sensitive P388/S variant [3]. |
別名 | Phomin |
分子量 | 479.61 |
分子式 | C29H37NO5 |
CAS No. | 14930-96-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 20 mg/mL (41.7 mM)
DMSO: 20 mg/mL (41.7 mM)
You can also refer to dose conversion for different animals. 詳細
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Cytochalasin B 14930-96-2 Cytoskeletal Signaling Arp2/3 Complex Phomin Inhibitor inhibitor inhibit