Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.
説明 | DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM. |
ターゲット&IC50 | KDM1A/LSD1:84 nM |
In vitro | DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony-forming ability and in inducing the differentiation of THP-1 cells than the 1R, 2S analogue [1]. |
In vivo | DDP-38003 demonstrates effectiveness in vivo upon oral administration, leading to a 62% increase in survival rates in mouse leukemia models via KDM1A inhibition. It has a half-life of 8 hours. A notable dose-dependent enhancement in survival rates of mice treated with DDP-38003 is observed, with survival rates escalating by 35% and 62% at doses of 11.25 and 22.50 mg/kg, respectively, showcasing its potential as a cancer therapeutic [1]. |
分子量 | 459.84 |
分子式 | C21H29Cl3N4O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (217.47 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DDP-38003 trihydrochloride Others DDP 38003 Trihydrochloride DDP 38003 trihydrochloride DDP-38003 Trihydrochloride DDP38003 DDP38003 Trihydrochloride DDP 38003 DDP38003 trihydrochloride DDP-38003 Inhibitor inhibitor inhibit