Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
説明 | DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3. |
In vitro | DS-437 increased total CD8+?and CD8+ PD-1+ T cells [2]. DS-437 was able to inhibit the methylation of an H4[1–24] peptide by the PRMT5–MEP50 complex under balanced conditions (cofactor and substrate concentrations set at their respective?Km?values) in a dose-dependent manner (IC50: 5.9 μM) [1]. |
In vivo | The combination of DS-437 and the anti-p185erbB2/neu?antibody 4D5 had even more dramatic effects. DS-437 (10 mg/kg; i.p.; 5 times a week) has some beneficial effects on inhibiting tumor growth [1]. |
分子量 | 397.45 |
分子式 | C15H23N7O4S |
CAS No. | 1674364-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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DS-437 1674364-87-4 Others DS437 DS 437 Inhibitor inhibitor inhibit