Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fodipir, the active metabolite of mangafodipir, plays a crucial role in the mechanism of mangafodipir-mediated cytoprotection, specifically mitigating cell death induced by 7β-hydroxycholesterol.
説明 | Fodipir, the active metabolite of mangafodipir, plays a crucial role in the mechanism of mangafodipir-mediated cytoprotection, specifically mitigating cell death induced by 7β-hydroxycholesterol. |
In vitro | Fodipir (Dp-dp; Dipyridoxyl diphosphate; 100 μM) demonstrates significant cytoprotective effects, effectively mitigating 7β-hydroxycholesterol (7β-OH)-induced cell death after 8 hours of treatment. It not only reduces cellular reactive oxygen species (ROS) production triggered by 7β-OH but also inhibits lysosomal membrane permeabilization (LMP), enhancing cell survival. Fodipir, as a principal metabolite of mangafodipir, plays a crucial role in the cytoprotection conferred by mangafodipir against 7β-OH-induced cytotoxicity. |
別名 | DPDP |
分子量 | 638.46 |
分子式 | C22H32N4O14P2 |
CAS No. | 118248-91-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Fodipir 118248-91-2 Others DPDP Inhibitor inhibitor inhibit