Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
説明 | Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP. |
ターゲット&IC50 | PNP (human):1.19 nM , PNP (monkey):0.66 nM , PNP (mouse):0.48 nM , PNP (rat):1.24 nM , PNP (dog):1.57 nM |
In vivo | In the hu-PBL-SCID mouse model, Forodesine (BCX-1777) demonstrates efficacy in extending lifespan by two-fold or greater. This compound exhibits outstanding oral bioavailability (63%) in mice. When administered at a single dose of 10 mg/kg, it significantly increases dGuo levels to around 5 μM. |
別名 | BCX-1777 hydrochloride, Immucillin-H hydrochloride |
分子量 | 302.71 |
分子式 | C11H15ClN4O4 |
CAS No. | 284490-13-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (55.07 mM), Sonication is recommended.
H2O: 16.67 mg/mL (55.07 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Forodesine hydrochloride 284490-13-7 Others BCX-1777 hydrochloride Forodesine Hydrochloride Immucillin-H hydrochloride BCX 1777 Hydrochloride Immucillin-H Hydrochloride BCX-1777 Hydrochloride BCX1777 Hydrochloride Inhibitor inhibitor inhibit