Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furthermore, Furamidine blocks cell proliferation in leukemia cell lines with different genetic lesions.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 18,000 |
5 mg | 約 35 days | ¥ 53,500 |
10 mg | 約 35 days | ¥ 97,000 |
説明 | Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furthermore, Furamidine blocks cell proliferation in leukemia cell lines with different genetic lesions. |
ターゲット&IC50 | PRMT5:166 µM (IC50), PRMT1:9.4 μM (IC50), PRMT4:>400 µM (IC50), PRMT6:283 µM (IC50) |
別名 | DB 75, DB75, NSC 305831, WR199385, Furamidine HCl |
分子量 | 377.27 |
分子式 | C18H18Cl2N4O |
CAS No. | 55368-40-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Furamidine dihydrochloride 55368-40-6 Furamidine Dihydrochloride Furamidine DB 75, DB75, NSC 305831, WR199385 DB 75, DB75, NSC 305831, WR-199385 Furamidine HCl DB 75, DB75, NSC 305831, WR 199385 Inhibitor inhibitor inhibit