Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 489,000 |
50 mg | 約10-14 週間 | ¥ 636,000 |
100 mg | 約10-14 週間 | ¥ 1,026,000 |
In vivo | Daily administration of Genz-882706 markedly attenuates experimental autoimmune encephalomyelitis (EAE) severity. In EAE-affected mice, Genz-882706 significantly lowers MCP-1, IL-6, IL-1β, and IP-10 levels in spinal cord homogenates, contrasting sharply with those treated with a vehicle. Conversely, TNF-α levels in the spinal cord notably increase following Genz-882706 treatment compared to the vehicle group. Furthermore, Genz-882706 administrations, at both 30 mg/kg and 100 mg/kg dosages, substantially decrease the population of microglia and monocytes/macrophages in the brain and spinal cord, standing out from vehicle and LPS controls. Additionally, Genz-882706 modestly diminishes CD80 expression on monocytes/macrophages within the brain. |
別名 | RA03546849 |
分子量 | 455.51 |
分子式 | C26H25N5O3 |
CAS No. | 2070864-35-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GENZ-882706 2070864-35-4 Tyrosine Kinase/Adaptors CSF-1R RA 03546849 GENZ 882706 RA-03546849 RA03546849 GENZ882706 Inhibitor inhibitor inhibit