Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 25,000 |
50 mg | 約6-8 週間 | ¥ 171,500 |
100 mg | 約6-8 週間 | ¥ 273,500 |
説明 | GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively. |
ターゲット&IC50 | GGT (human):(ki)170 μM |
In vitro | GGsTop is a non-toxic compound, completely inhibits WT human GGT in 1 min at 1 mM, but less potent against the K562S mutant [2]. |
In vivo | GGsTop also decreases 4-HNE and TNF-α production and decreases hepatic necrosis in rats. GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats [3]. |
別名 | Nahlsgen |
分子量 | 331.26 |
分子式 | C13H18NO7P |
CAS No. | 926281-37-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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GGsTop 926281-37-0 Others Nahlsgen Inhibitor inhibitor inhibit