Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM). GNE-618 depletes NAD levels and induces tumor cell death. It has anti-tumor activity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約8-10 週間 | ¥ 41,000 |
25 mg | 約8-10 週間 | ¥ 146,500 |
50 mg | 約8-10 週間 | ¥ 190,000 |
100 mg | 約8-10 週間 | ¥ 284,500 |
1 mL * 10 mM (in DMSO) | 約8-10 週間 | ¥ 42,000 |
ターゲット&IC50 | NAMPT:6 nM |
In vivo | In the STO#81 patient-derived gastric cancer model, GNE-618 administered orally at a dosage of 100 mg/kg twice daily for 5 days significantly inhibits tumor growth by 88%, while having minimal effects on body weight. |
分子量 | 460.43 |
分子式 | C21H15F3N4O3S |
CAS No. | 1362151-42-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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GNE-618 1362151-42-5 Metabolism NAMPT GNE 618 GNE618 Inhibitor inhibitor inhibit