Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GPR84 antagonist 8 is a selective GPR84 antagonist.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 383,500 |
50 mg | 約6-8 週間 | ¥ 500,500 |
100 mg | 約6-8 週間 | ¥ 643,000 |
In vitro | GPR84 antagonist 8 is shown to effectively counteract the decrease in cAMP production triggered by 6-OAU in GPR84-CHO cells, hinting at its ability to inhibit GPR84's action. To examine its potential in mitigating GPR84 activation's pro-inflammatory effects in macrophages, bone marrow-derived macrophages (BMDMs) pretreated with LPS were exposed to 10μM of the antagonist for 30 minutes prior to the introduction of 1μM 6-OAU. Western Blot analysis indicated that GPR84 antagonist 8 notably reduces the phosphorylation of AKT and ERK prompted by 6-OAU, showcasing its partial blockade. Given GPR84's prominence in immune cells as part of the G protein-coupled receptor family associated with metabolism, utilizing GPR84 antagonist 8 emerges as a promising anti-inflammatory approach against various inflammatory diseases. The antagonist's effectiveness and specificity were further validated through cAMP assay trials conducted on GPR84-CHO cells. |
分子量 | 421.45 |
分子式 | C23H23N3O5 |
CAS No. | 1445846-30-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (11.86 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GPR84 antagonist 8 1445846-30-9 Endocrinology/Hormones GPCR/G Protein GPR GPR-84 antagonist 8 Inhibitor inhibitor inhibit