store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
500 μg | 約 35 days | ¥ 17,500 |
1 mg | 約 35 days | ¥ 32,500 |
5 mg | 約 35 days | ¥ 129,500 |
10 mg | 約 35 days | ¥ 225,000 |
説明 | GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. |
ターゲット&IC50 | PPARα (human):50 nM (EC50), PPARα (mouse):5 nM (EC50), PPARα (murine):0.005 μM (EC50), PPARγ:1.5 (EC50), PPARδ:2.6 (EC50s) |
In vitro | GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.005, 1.5, and 2.6 μM, respectively. Similarly, it shows activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC50s of 0.05, 1, and 1.4 μM, respectively[2].In the CD8+ T-cell line TK.1 cells, treatment with GW9578 (10 nM-1 μM for 24 hours) induces a dose-dependent increase in the amount of relative luciferase activity[3].On the other hand, treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM for 2 hours) results in a significant decrease in IL-2 production compared to control cells[3]. |
別名 | GW9578, GW-9578 |
分子量 | 492.62 |
分子式 | C26H34F2N2O3S |
CAS No. | 247923-29-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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GW 9578 247923-29-1 DNA Damage/DNA Repair Metabolism PPAR GW9578 GW-9578 Inhibitor inhibitor inhibit