Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM).
ターゲット&IC50 | eNOS (human):544 μM (Kd) |
In vitro | GW274150 demonstrates significant selectivity for iNOS over eNOS and nNOS, with >260-fold and 219-fold selectivity in rat tissues, and >100-fold and >80-fold selectivity in human tissues, against eNOS and nNOS, respectively. Additionally, GW274150 phosphate effectively inhibits intracellular iNOS in J774 cells in a time-dependent manner, achieving IC50 values of 0.2±0.04 μM. |
分子量 | 317.3 |
分子式 | C8H20N3O6PS |
CAS No. | 438542-15-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (315.16 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GW274150 phosphate 438542-15-5 Immunology/Inflammation NOS GW274150 Phosphate GW-274150 Phosphate GW-274150 phosphate GW 274150 Phosphate Inhibitor inhibitor inhibit