keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
1 mg | 約5 days | ¥ 13,000 | |
5 mg | 約5 days | ¥ 37,500 | |
10 mg | 約5 days | ¥ 57,500 | |
25 mg | 約5 days | ¥ 111,500 | |
50 mg | 約5 days | ¥ 150,000 | |
100 mg | 約5 days | お問い合わせ | |
200 mg | 約5 days | お問い合わせ |
説明 | Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. |
In vitro | Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia, after binding to its receptor Gcgr. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis [1]. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes and that also increases phosphorylation of HNF4α [3]. |
In vivo | Compared with PBS control, High-dose (1 mg/kg) Glucagon lowers glycemia and stimulates insulin secretion in ambient-fed mice. Low-dose (20 μg/kg) Glucagon enhances glycemia and does not stimulate insulin secretion in ambient-fed mice [4]. |
別名 | Porcine glucagon, Glucagon |
分子量 | 3482.75 |
分子式 | C153H225N43O49S |
CAS No. | 16941-32-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (14.36 mM), Sonication is recommended.
H2O: 20 mg/mL (5.74 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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