Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gosogliptin is a potent and selective dipeptidyl peptidase-IV (DPP-IV) inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
In vitro | Gosogliptin is a potent, orally active inhibitor of DPP-IV, displaying over 200-fold selectivity against other DPP family members (DPP-2, DPP-3, DPP-8, and DPP-9) and related serine proteases, such as fibroblast activation protein, aminopeptidase P, and propyl oligopeptidase. This compound effectively inhibits plasma DPP-4 activity in a rapid and reversible manner following oral administration to rats, dogs, and monkeys. Gosogliptin enhances insulin secretion and glucose tolerance in various nonclinical models. Its mechanism involves competitive and selective inhibition of DPP-IV, key for degrading incretin peptides GLP-1 and glucose-dependent insulinotropic polypeptide, thereby influencing glucose homeostasis. |
別名 | PF-00734200, PF-734200 |
分子量 | 366.41 |
分子式 | C17H24F2N6O |
CAS No. | 869490-23-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Gosogliptin 869490-23-3 Others PF00734200 PF-00734200 PF 00734200 PF-734200 PF 734200 PF734200 Inhibitor inhibitor inhibit