Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 111,000 | |||
10 mg | 在庫あり | ¥ 159,000 | |||
25 mg | 在庫あり | ¥ 248,000 | |||
50 mg | 在庫あり | ¥ 342,000 |
説明 | INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15. |
ターゲット&IC50 | Heregulin:0.24 μM |
In vitro | The dual ADAM inhibitor INCB3619 inhibits heregulin cleavage with an IC50 value of 0.24 μM[1].Treating A549 cells in serum-free culture with varying concentrations of gefitinib and INCB3619 (2-10 µM) for 96 hours revealed that INCB3619 sensitizes A549 cells to gefitinib[1]. |
In vivo | INCB3619 was administered subcutaneously using ALZET osmotic pumps at doses of 30 or 60 mg/kg/day for 14 days. The results showed that the ADAM inhibitor INCB3619 inhibited gefitinib-resistant HER3 autocrine mechanism, exerting antitumor activity in vivo, and sensitizing tumors to chemotherapy drugs[1]. |
別名 | INCB-3619, INCB 3619 |
分子量 | 413.47 |
分子式 | C22H27N3O5 |
CAS No. | 791826-72-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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INCB3619 791826-72-7 Immunology/Inflammation Immunology/Inflammation related INCB-3619 INCB 3619 Inhibitor inhibitor inhibit