Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 486,500 |
50 mg | 約8-10 週間 | ¥ 638,000 |
100 mg | 約8-10 週間 | ¥ 849,500 |
説明 | IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans. |
別名 | IWP051 |
分子量 | 355.3 |
分子式 | C17H11F2N5O2 |
CAS No. | 1354041-91-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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IWP-051 1354041-91-0 IWP 051 IWP051 Inhibitor inhibitor inhibit