store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
説明 | Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM). |
ターゲット&IC50 | FLT3:1 nM, c-Kit:20 nM, Aurora A:120 nM, PDGFRβ:13 nM, Aurora B (Y156H):12 nM, Aurora B:7 nM, PDGFRα:11 nM, CSF1R:3 nM, Aurora C:1 nM, VEGFR1:1 nM, VEGFR3:43 nM, VEGFR2:2 nM |
別名 | ABT-348 hydrochloride |
分子量 | 525 |
分子式 | C25H22ClFN6O2S |
CAS No. | 1847485-91-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41.67 mg/mL (79.37 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ilorasertib hydrochloride 1847485-91-9 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase ABT348 Hydrochloride ABT 348 Hydrochloride ABT-348 Hydrochloride ABT-348 hydrochloride Ilorasertib Hydrochloride Inhibitor inhibitor inhibit