Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 12,000 | |||
10 mg | 在庫あり | ¥ 19,500 | |||
25 mg | 在庫あり | ¥ 39,500 | |||
50 mg | 在庫あり | ¥ 61,500 | |||
100 mg | 在庫あり | ¥ 98,500 | |||
500 mg | 在庫あり | ¥ 222,500 |
説明 | Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy. |
ターゲット&IC50 | placental serotonin transporter (human):32 nM |
In vitro | In DLD-1, HCT-116, and SW-480 cell lines, Imipramine (0.5-300 μM; 3 days) inhibited cell viability, with HCT-116 being more sensitive to it compared to DLD-1 and SW-480[1]. |
In vivo | In male C57BL/6 mice (6-8 weeks old) exposed to repeated social defeat (RSD) and home cage control (HCC), Imipramine (20 mg/kg or 15 mg/kg; administered intraperitoneally or orally, daily for 24 days) reversed RSD-induced social avoidance behavior, significantly increasing interaction time, and significantly decreased stress-induced mRNA levels for IL-6 in brain microglia[4]. |
別名 | HSDB 3100, Melipramine, HSDB3100, Dimipressin, HSDB-3100 |
分子量 | 280.41 |
分子式 | C19H24N2 |
CAS No. | 50-49-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (356.62 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Imipramine 50-49-7 Apoptosis HSDB 3100 Melipramine HSDB3100 Dimipressin HSDB-3100 Inhibitor inhibitor inhibit