Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.
ターゲット&IC50 | αvβ8:7.4, αvβ3:8.4, αvβ6:7.8(pIC50), αvβ5:8.4 |
In vivo | In vivo pharmacokinetic studies conducted on CD rats have demonstrated that the racemic compound Integrin-IN-2 (compound 39) displays a low plasma clearance rate of 8 mL/(min·kg), coupled with a low to moderate distribution volume of 0.5 L/kg. It exhibits a moderate half-life of 1.8 hours and an exceptionally high bioavailability of 98%. |
分子量 | 458.55 |
分子式 | C27H30N4O3 |
CAS No. | 2378617-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Integrin-IN-2 2378617-67-3 Others Integrin IN 2 IntegrinIN2 Inhibitor inhibitor inhibit