Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
説明 | Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1]. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
別名 | RG7440-NH2, GDC-0068-NH2 |
分子量 | 415.92 |
分子式 | C21H26ClN5O2 |
CAS No. | 1001382-14-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Ipatasertib-NH2 1001382-14-4 Others RG7440-NH2 Ipatasertib NH2 Ipatasertib-NH-2 IpatasertibNH2 GDC-0068-NH2 Inhibitor inhibitor inhibit