Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 31,000 |
5 mg | 約 5 days | ¥ 52,500 |
10 mg | 約 5 days | ¥ 86,500 |
50 mg | 約6-8 週間 | ¥ 181,000 |
100 mg | 約6-8 週間 | ¥ 271,000 |
1 mL * 10 mM (in DMSO) | 約 5 days | ¥ 58,000 |
説明 | Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. |
ターゲット&IC50 | Na+, K+-ATPase:0.11 μM |
In vitro | Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney (IC50: 0.43 ± 0.15 μM). Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase[2]. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3]. |
In vivo | Istaroxime (PST2744) causes a progressive to enhance in +dP/dtmax throughout the infusion. That reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3]. |
別名 | PST2744 hydrochloride |
分子量 | 396.96 |
分子式 | C21H33ClN2O3 |
CAS No. | 374559-48-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (113.36 mM)
You can also refer to dose conversion for different animals. 詳細
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Istaroxime hydrochloride 374559-48-5 Others PST 2744 Hydrochloride PST-2744 Hydrochloride Istaroxime Hydrochloride PST2744 Hydrochloride PST2744 hydrochloride Inhibitor inhibitor inhibit