Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 28,500 |
5 mg | 約 35 days | ¥ 124,000 |
10 mg | 約 35 days | ¥ 218,000 |
25 mg | 約 35 days | ¥ 454,500 |
説明 | L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase. |
ターゲット&IC50 | P. falciparum:297 nM |
In vivo | Administering 100 μg of L-canaline via intraseptal injection to male Sprague-Dawley rats results in a significant 90% reduction in ornithine aminotransferase activity in septum tissues, assessed in specimens euthanized one hour post-treatment. Moreover, L-canaline lowers the aspartic acid levels in the medulla oblongata tissues of male Wistar rats, although it does not influence the stimulated release of this nonprotein amino acid into the tissues. |
分子量 | 134.13 |
分子式 | C4H10N2O3 |
CAS No. | 496-93-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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L-Canaline 496-93-5 Others L Canaline LCanaline Inhibitor inhibitor inhibit