Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor.
説明 | LE 300 represents a structurally novel type of antagonists acting preferentially at the dopamine D(1)/D(5)receptors and the serotonin 5-HT(2A)receptor. |
ターゲット&IC50 | D1 receptor:1.9 nM (Ki,Human), 5-HT2A:8.32 (pA2,rat), D5 receptor:7.5 nM (Ki,Human) |
In vitro | The Kis of LE 300 are 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. In a rat tail artery experiment, the pA2 value of LE 300 at the 5-HT2A receptor was 8.32[2]. |
分子量 | 290.4 |
分子式 | C20H22N2 |
CAS No. | 274694-98-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1eq. HCl: <15 mg/ml(51.65 mM)
DMSO: <30 mg/ml(103.30 mM)
You can also refer to dose conversion for different animals. 詳細
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LE 300 274694-98-3 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor inhibit Inhibitor LE300 LE-300 Serotonin Receptor 5-hydroxytryptamine Receptor inhibitor