Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.
ターゲット&IC50 | mGluR3:2.5 nM (ki), mGluR2:5.3 nM (ki) |
In vivo | LY3020371 hydrochloride (LY3020371) administered via intraperitoneal injection at doses of 3 mg/kg and 10 mg/kg, 2 hours prior, significantly promotes wakefulness, notably decreasing NREM sleep in Wistar rats during the light phase[3]. Intravenous administration of LY3020371 hydrochloride at a dosage range of 3-15 mg/kg in rats results in cerebrospinal fluid concentrations predicted to efficiently inhibit mGlu2/3 receptors[1]. |
分子量 | 395.81 |
分子式 | C15H16ClF2NO5S |
CAS No. | 1377615-44-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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LY3020371 hydrochloride 1377615-44-5 Neuroscience GluR LY-3020371 Hydrochloride LY 3020371 Hydrochloride LY-3020371 hydrochloride LY3020371 Hydrochloride Inhibitor inhibitor inhibit