Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders.
説明 | Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase).Liarozole dihydrochloride is an imidazole derivative; it is being investigated as a non-hormonal agent in prostate cancer and in the treatment of various other cancers and skin disorders. |
ターゲット&IC50 | CYP26:7 μM (IC50) |
In vitro | Liarozole inhibits 17a-hydroxylase activity in bovine adrenal microsomes (IC50=0.15 μM) [1]. Liarozole has modest inhibitory activity on cholesterol synthesis in human hepatoma cells(IC50=5 μM)[1].Liarozole inhibits the metabolism of retinoic acid to more polar metabolites in hamster liver microsomes (IC50=2.2 μM), rat liver homogenate (IC50=0.14 μM), dunning prostate cancer homogenate (IC50=0.26 μM) and MCF-7 human breast cancer cells (almost complete block at 10μM) [1]. |
別名 | R75251 dihydrochloride |
分子量 | 381.69 |
分子式 | C17H15Cl3N4 |
CAS No. | 1883548-96-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (131.00 mM), Sonication is recommended.
H2O: 50 mg/mL (131.00 mM)
You can also refer to dose conversion for different animals. 詳細
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Liarozole dihydrochloride 1883548-96-6 Others R-75251 R75251 dihydrochloride R-75251 Dihydrochloride Liarozole Liarozole Dihydrochloride R 75251 Dihydrochloride R 75251 R75251 Dihydrochloride R75251 Inhibitor inhibitor inhibit