Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 555,500 |
50 mg | 約10-14 週間 | ¥ 730,000 |
100 mg | 約10-14 週間 | ¥ 987,000 |
説明 | M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity. |
In vitro | M-525 (3-300 nM; 24 h) is potent and effective in suppressing the expression of MEIS1 and HOX genes in MV4 11 cells carrying the MLL-AF4 fusion and in MOLM-13 cells carrying the MLL-AF9 fusion. M-525 achieves an IC50 of 3 nM in the MV4 11 cell line and has an IC50 of 2 μM in the HL-60 cell line. It shows high cellular specificity over non-MLL leukemia cells. |
分子量 | 734.92 |
分子式 | C39H51FN6O5S |
CAS No. | 2173582-08-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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M-525 2173582-08-4 Others M525 M 525 Inhibitor inhibitor inhibit