Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 39,000 |
5 mg | 約 35 days | ¥ 173,500 |
10 mg | 約 35 days | ¥ 305,500 |
25 mg | 約 35 days | ¥ 670,500 |
説明 | MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM). |
In vitro | MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner (IC50: 1.7 and 17 nM in the absence and presence of 10% serum, respectively). MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract. |
In vivo | MF498 on inflammation in adjuvant-caused arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA). MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. |
分子量 | 603.69 |
分子式 | C32H33N3O7S |
CAS No. | 915191-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (51.35 mM)
You can also refer to dose conversion for different animals. 詳細
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MF498 915191-42-3 Others MF-498 MF 498 Inhibitor inhibitor inhibit