Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 45,000 |
25 mg | 約6-8 週間 | ¥ 252,500 |
50 mg | 約6-8 週間 | ¥ 330,500 |
100 mg | 約6-8 週間 | ¥ 500,500 |
説明 | MK0343 is an orally bioavailable GABAA receptor subtype-selective partial agonist and is a non-sedating anxiolytic. |
ターゲット&IC50 | GABAA α4 (rat):78 nM(ki), GABAA α6 (rat):980 nM(ki), GABAA α2 (rat):0.4 nM(ki), GABAA α3 (rat): 0.21 nM(ki), GABAA α5 (rat):0.23 nM(ki), GABAA α1 (rat):(ki)0.22 nM |
In vivo | MK0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABAA receptors, measured using an in vivo [3H]flumazenil binding assay. It has an Occ50 of 2.2?mg/kg p.o. and a corresponding plasma EC50 of 115?ng/mL . |
別名 | MRK-409 |
分子量 | 397.38 |
分子式 | C19H17F2N7O |
CAS No. | 233275-76-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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MK-0343 233275-76-8 Others MRK-409 MRK 409 MRK409 MK 0343 MK0343 Inhibitor inhibitor inhibit