Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK-4074 is a liver-specific acetyl-CoA carboxylase ACC1 and ACC2 inhibitor(IC50 of 3 nM).
説明 | MK-4074 is a liver-specific acetyl-CoA carboxylase ACC1 and ACC2 inhibitor(IC50 of 3 nM). |
ターゲット&IC50 | ACC1:3 nM |
In vitro | MK-4074 is highly liver specific because it is a substrate of organic anion transport protein (OATP) transporters that are present only in hepatocytes, and excretion of MK-4074 from hepatocytes into bile is dependent on the MRP2 efflux transporter[1]. |
In vivo | MK-4074 orally at 30 mg/kg reduces hepatic DNL by 83%, 70%, and 51% at 4, 8, and 12 hr post-dose, respectively. Single oral doses of MK-4074 at 30 and 100 mg/kg significantly increases plasma total ketones, a surrogate biomarker for hepatic FAO, by 1.5-fold to 3-fold for up to 8 hr[1]. |
分子量 | 565.62 |
分子式 | C33H31N3O6 |
CAS No. | 1039758-22-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.3 mg/mL (147.27 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MK-4074 1039758-22-9 Others MK4074 MK 4074 Inhibitor inhibitor inhibit