Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約5 days | ¥ 68,500 |
50 mg | 約5 days | ¥ 181,000 |
100 mg | 約5 days | ¥ 280,000 |
説明 | MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM). |
ターゲット&IC50 | MALT1:5 nM, MALT1 (329-728):42 nM(kd), MALT1 (329-728-W580S):(kd)13 nM |
In vitro | MLT-748 (2 μM, 24 hours) enhances the phosphorylation of p65 and IκBα in MALT1mut/mut patient immortalized B cells. MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S (EC50: 69 nM). MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with an affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM). |
分子量 | 492.32 |
分子式 | C19H19Cl2N9O3 |
CAS No. | 1832578-30-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (507.80 mM)
You can also refer to dose conversion for different animals. 詳細
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MLT-748 1832578-30-9 Others MLT748 MLT 748 Inhibitor inhibitor inhibit