Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Methylmoranoline is an inhibitor of α-glucosidase.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
500 μg | 約 35 days | ¥ 35,500 |
1 mg | 約 35 days | ¥ 63,000 |
5 mg | 約 35 days | ¥ 273,500 |
説明 | N-Methylmoranoline is an inhibitor of α-glucosidase. |
In vivo | N-Methylmoranoline(MOR-14) dose-dependently decreased the alpha-1,6-glucosidase activity in rabbit heart extract.?The myocardial uptake of a considerable amount of MOR-14 sufficient to fully inhibit alpha-1,6-glucosidase.?To assess the infarct size-reducing effect of MOR-14, 54 rabbits were subjected to 30-minute coronary occlusion followed by 48-hour reperfusion.?Preischemic treatment with 25, 50, and 100 mg/kg of MOR-14 dose-dependently reduced the infarct size (to 26+/-4%, 19+/-3%, and 14+/-2% of the area at risk, respectively), compared with the saline control (45+/-5%) without altering the blood pressure or heart rate.?Another 40 rabbits given 100 mg of MOR-14 or saline 10 minutes before ischemia were euthanized at 10 or 30 minutes of ischemia for biochemical analysis.?MOR-14 decreased the alpha-1,6-glucosidase activity to approximately 20% in vivo, reduced the glycogen breakdown, and attenuated the lactate accumulation at both 10 and 30 minutes of ischemia[1]. |
別名 | MOR 14, N-Methyl-1-deoxynojirimycin, N-Methylmoranolin |
分子量 | 177.2 |
分子式 | C7H15NO4 |
CAS No. | 69567-10-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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N-Methylmoranoline 69567-10-8 Others MOR 14 N-Methyl-1-deoxynojirimycin NMethylmoranoline N-Methylmoranolin MOR-14 N Methylmoranoline MOR14 Inhibitor inhibitor inhibit