store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
2 mg | 在庫あり | ¥ 11,500 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 32,000 | |||
25 mg | 在庫あり | ¥ 68,500 | |||
50 mg | 在庫あり | ¥ 114,000 | |||
100 mg | 在庫あり | ¥ 182,500 |
説明 | NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders. |
ターゲット&IC50 | C5aR (human):11.6 nM |
In vitro | NDT 9513727 inhibited C5a-stimulated responses, including guanosine 5′-3-O-(thio)triphosphate binding, Ca2+ mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC50s from 1.1 to 9.2 nM, respectively[1]. |
In vivo | NDT 9513727 (3-30 mg/kg) effectively inhibited C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo[1]. |
別名 | NDT9513727, NDT-9513727 |
分子量 | 573.68 |
分子式 | C36H35N3O4 |
CAS No. | 439571-48-9 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 30 mg/mL (52.26 mM)
DMSO: 80 mg/mL (139.37 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NDT 9513727 439571-48-9 Immunology/Inflammation Complement System NDT9513727 NDT-9513727 Inhibitor inhibitor inhibit