Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).
説明 | NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27). |
In vitro | The selective non-nucleotide P2Y(11) agonist NF546 was identified.?NF546 had a pEC(50) of 6.27 and is relatively selective for P2Y(11) over P2Y(1), P2Y(2), P2Y(4), P2Y(6), P2Y(12), P2X(1), P2X(2), and P2X(2)-X(3).?The pA(2) of NF340 was 8.02 against ATPgammaS and 8.04 against NF546 (calcium assays).?NF546 was further tested for P2Y(11)-mediated effects in monocyte-derived dendritic cells.?Similarly to ATPgammaS, NF546 led to thrombospondin-1 secretion and inhibition of lipopolysaccharide-stimulated interleukin-12 release, whereas NF340 inhibited these effects.?Further, for the first time, it was shown that ATPgammaS or NF546 stimulation promotes interleukin 8 (IL-8) release from dendritic cells, which could be inhibited by NF340. |
分子量 | 1184.78 |
分子式 | C47H48N6Na4O17P4 |
CAS No. | 1006028-37-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NF546 1006028-37-0 Others NF-546 NF 546 Inhibitor inhibitor inhibit