Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Narlaprevir is an effective, selective, and orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM).
説明 | Narlaprevir is an effective, selective, and orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM). |
ターゲット&IC50 | Ketoamide:7 nM (Ki), NS3 protease:40 nM (EC90), NS3 protease:6 nM (Ki), Replicon RNA:40 nM (EC90) |
In vitro | Narlaprevir administration resulted in a robust HCV-RNA decline and high SVR rates when followed by standard of care in both treatment-experienced and treatment-naive HCV genotype 1-infected patients. HCV Narlaprevir is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metabolized by the cytochrome P450-3A4 system. |
別名 | SCH 900518 |
分子量 | 707.96 |
分子式 | C36H61N5O7S |
CAS No. | 865466-24-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (70.63 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Narlaprevir 865466-24-6 Others SCH 900518 SCH-900518 SCH900518 Inhibitor inhibitor inhibit