Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
ターゲット&IC50 | ACAT2:368 nM (EC50), ACAT1:9 nM (EC50) |
In vitro | In H295R human adrenocortical carcinoma cells, Nevanimibe(ATR-101) decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity.?Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis[1]. |
別名 | ATR-101, PD-132301 |
分子量 | 421.62 |
分子式 | C27H39N3O |
CAS No. | 133825-80-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Nevanimibe 133825-80-6 Others PD 132301 ATR-101 PD-132301 ATR 101 PD132301 ATR101 Inhibitor inhibitor inhibit