Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function .
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | Norverapamil is a blocker of L-type calcium channel and an inhibitor of P-glycoprotein (P-gp) function . |
In vitro | Verapamil's R isomer and its metabolite norverapamil have substantially less calcium channel blocking activity yet were similarly active as verapamil at inhibiting macrophage-induced drug tolerance.?Our finding that verapamil inhibits intracellular M. tuberculosis growth and tolerance suggests its potential for treatment shortening.?Norverapamil, R-verapamil, and potentially other derivatives present attractive alternatives that may have improved tolerability[1]. |
In vivo | Norverapamil is?a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively[2]. |
別名 | D591, (±)-Norverapamil |
分子量 | 440.58 |
分子式 | C26H36N2O4 |
CAS No. | 67018-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Norverapamil 67018-85-3 Membrane transporter/Ion channel Metabolism Calcium Channel D591 D 591 D-591 (±)-Norverapamil Inhibitor inhibitor inhibit