keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 54,500 |
5 mg | 在庫あり | ¥ 122,500 |
10 mg | 在庫あり | ¥ 176,500 |
25 mg | 在庫あり | ¥ 273,500 |
50 mg | 在庫あり | ¥ 363,000 |
100 mg | 在庫あり | ¥ 496,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 196,500 |
説明 | Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist. |
ターゲット&IC50 | AT2:7 nM(Ki) |
In vitro | Novokinin relaxed a mesenteric artery isolated from the spontaneously hypertensive rat (SHR) at 10(-5) M, and reduced SHR blood pressure at a dose of 0.1 mg/kg (po.) emulsified in 30% egg yolk[1]. |
In vivo | The hypotensive effect of novokinin in normotensive mice was not observed in the AT2 receptor-knockout mice. Its antihypertensive and vasorelaxing activities in SHR were also blocked by CAY-10441, an antagonist of the IP receptor for prostaglandin I2 PGI2 suggesting that these activities are mediated by the AT2 receptor, followed by the prostaglandin I2-IP receptor pathway. Novokinin suppressed food intake after icv. or po. administration in mice. The anorexigenic activity was not observed in the AT2 receptor- knockout mice, but was observed in the AT 1 receptor-knockout mice. The anorexigenic activities of novokinin and angiotensin II were blocked by PD123319, and ONO-AE3-208, an antagonist of the EP4 receptor suggesting that the anorexigenic activities of the AT2 agonists are mediated by the PGE 2-EP4 receptor pathway downstream of the AT2 receptor. Novokinin given icv. in mice antagonized the antinociceptive effect of morphine[1]. |
別名 | Novokinin acetate (358738-77-9 free base) |
分子量 | 856.02 |
分子式 | C41H65N11O9 |
CAS No. | T23077L |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13 mg/mL (15.19 mM)
You can also refer to dose conversion for different animals. 詳細
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Novokinin acetate T23077L Endocrinology/Hormones RAAS Novokinin acetate (358738-77-9 free base) Novokinin Acetate 358738-77-9 358738-77-9 free base Inhibitor inhibitor inhibit