Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression.
説明 | PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively suppressing PCSK9 expression. |
In vitro | PF-06446846 suppresses the secretion of PCSK9 by Huh7 cells (IC50: 0.3 μM)[1]. |
In vivo | PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner. It also decreases total cholesterol levels[1]. |
分子量 | N/A |
分子式 | C22H20CIN7O.XHCl |
CAS No. | 1632250-50-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 90.0 mg/mL (191.3 mM), Sonication is recommended.
DMSO: 225.0 mg/mL (478.4 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-06446846 hydrochloride 1632250-50-0 Others PF-06446846 Hydrochloride PF 06446846 Hydrochloride PF06446846 hydrochloride PF06446846 Hydrochloride PF 06446846 hydrochloride Inhibitor inhibitor inhibit