Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 83,500 | |||
25 mg | 在庫あり | ¥ 176,000 | |||
50 mg | 在庫あり | ¥ 271,000 | |||
100 mg | 在庫あり | ¥ 420,000 |
説明 | PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin. |
ターゲット&IC50 | CA IX:25 nM, Topo II unknotting activity:100 μM |
In vitro | PNU-159682 inhibits a panel of human tumor cell lines (IC70 values in the range of 0.07-0.58 nM). PNU-159682 is 2,360- to 790-fold and 6,420- to 2,100-fold more potent than MMDX and doxorubicin, respectively. PNU-159682 displays cytotoxic effect on CAIX-expressing SKRC-52 cells (IC50: 25 nM). PNU-159682 (10 μM)-DNA adducts contain one or two drug molecules bound to double-stranded DNA. PNU-159682 (100 μM) weakly inhibits topoisomerase II unknotting activity [1][2][3]. |
In vivo | PNU-159682 (25 nmol/kg) shows an effective antitumor effect in mice bearing SKRC-52 xenografted tumors. PNU-159682 (15 μg/kg, i.v.) displays antitumor activity in mice bearing disseminated murine L1210 leukemia and in MX-1 human mammary carcinoma xenografts at 4 μg/kg[1][3]. |
分子量 | 641.62 |
分子式 | C32H35NO13 |
CAS No. | 202350-68-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 96.7 mg/mL (150.71 mM)
You can also refer to dose conversion for different animals. 詳細
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PNU-159682 202350-68-3 DNA Damage/DNA Repair Topoisomerase PNU 159682 inhibit non-Hodgkin’s lymphoma PNU159682 ADCs Toxin acute myeloid leukemia ADC Payload EDV nanocell AML Inhibitor ADC Cytotoxin NMS249 NHL inhibitor